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TIMP-1 and TIMP-2 tissue inhibitors of metalloproteinases are upregulated, further tipping the balance toward matrix preservation

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they observed that the mean enzymatic activities of xenobiotic metabolizing enzymes such as cytochrome P450 1A1 (CYP1A1), aromatase (CYP19A1), and glutathione-S-transferase (GST) were lower in three placental microsomes and subcellular membrane fractions