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Chronic treatment with DHF (6 g/day) in murine models demonstrated reduced eosinophilic pulmonary inflammation, serum IgE, IL-4 and IL-13 levels and an increase in IFN- production in cell cultures from the lung in response to antigen stimulation [112]

The study concluded that tirzepatide was indeed associated with worsening of existing DR: 1.1% (n=33) of patients treated with tirzepatide developed PDR vs