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Moreover, Emir et al

Consult your healthcare provider before using milk thistle, particularly if you take other medications or plan long-term use, since supplement quality, dosage, and safety are not FDA-regulated

doi: 10.1248/bpb.33.1938

This can lead to numbness and tingling in your hands and feet, mental confusion, weight loss, and generally feeling wiped out and weak, as reported by the Mayo Clinic

Serum 7 alpha-hydroxy-4-cholesten-3-one concentrations in the evaluation of bile acid malabsorption in patients with diarrhoea: correlation to SeHCAT test