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It promotes the formation of new blood vessels at injury sites, modulates nitric oxide production, and upregulates growth-hormone receptors on tendon and ligament fibroblasts

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Apitegromab is the first of this class to seek FDA approval in spinal muscular atrophy ( The focus has shifted to their use in obesity, both alone an in combination with the backbone GLP- 1 RA ( The companies developing the medications for this indication are also interested in their use to sustain weight loss after stopping the GLP- 1 RA ( The medications targeting the myostatin-activin pathway act in different ways

It may increase the risk of diabetic ketoacidosis in these patients [see Warnings and Precautions (5.1)]

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