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No dosage adjustment is recommended for renal or hepatic impairment, though patients should be monitored for dehydration-related acute kidney injury during significant gastrointestinal adverse effects

It is estimated that clinical trials evaluating liver-related events in patients with MASLD and compensated or decompensated cirrhosis would require a minimum recruitment of 2,886 patients with at least four years of follow-up and 1,602 patients with at least two years of follow-up, respectively

Compounded medications are not FDA-approvedthey are legally prepared by licensed 503A compounding pharmacies under federal guidelines when FDA-approved versions are unavailable or unaffordable

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