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However, the minor allele at rs12720356 was found to have no effect on STAT phosphorylation or cytokine production, while the protective allele at rs3456443 did reduce phosphorylation and cytokine stimulation in peripheral blood immune cells (121)

Nutritional support including biotin, iron, and zinc where deficient

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Reduced effectiveness despite consistent dosing can also indicate degradation, though this is harder to confirm objectively

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