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Topical is the more evidence-supported route, especially for skin endpoints

Another potential problem of using senolytics is an acceleration of stem cell exhaustion. Without clearance of apoptotic bodies, secondary necrosis could result in the release of proinflammatory, danger-associated molecular patterns, further exacerbating systemic chronic inflammation

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Studied in models involving hepatocyte growth factor pathway activity, c-Met receptor signaling, and neurotrophic response systems