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Omega-3 polyunsaturated fatty acids (PUFAs) potentially modulate neurobiological pathways implicated in the coexistence of migraine with depression and/or anxiety through several mechanisms

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The primary management involves L-carnitine supplementation to clear metabolic toxins and strictly avoiding prolonged fasting to prevent metabolic crises

Upon stimulation by Th17 and Th1 cytokines, keratinocytes activate intracellular signaling pathways particularly NF-B, MAPK, and STAT3 which regulate gene transcription involved in inflammation, proliferation, and cell survival