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3 Epigenetics Curcumin acts as a potent multi-target epigenetic modulator influencing gene expression through four major mechanisms: it inhibits DNA methyltransferases DNA (Cytosine-5)-Methyltransferase 1 DNA (Cytosine-5)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3 Beta (DNMT1, DNMT3A, DNMT3B), leading to demethylation and reactivation of silenced tumor-suppressor genes