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In addition it can happen that we produce "Parietal cell Antibodies" and "Intrinsic Factor Antibodies" which totally wipes out any chance of absorbing the B12

Goldstein AL, Hannappel E, Kleinman HK (2005)

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If the solution, which should be perfectly clear, becomes cloudy, changes color, or has visible particulates, it should be discarded immediately as it may be contaminated or degraded