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[14] Small clinical trials indicate that maternal supplementation of 4,000 IU day or staggered 50,000 IU oral doses can safely maintain 25-hydroxyvitamin D above 30 ng mL without inducing hypercalcaemia, whereas single injections of 300,000 IU are reserved for severe malabsorption emergencies when benefits outweigh theoretical teratogenic risk

Further studies employing an ex-vivo skin model supported these findings, suggesting a notable increase in collagen IV synthesis at the dermal-epidermal junction when exposed to the optimized GHK-Cu and LMW HA mixture