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Instead, activation energy barriers largely prevent their interaction and, thus, the approach to equilibrium (Floh, Enzyme-based redox signaling Signaling requires the reversible modification of a sensor and the subsequent activation of transducer and effector molecules (Figure 1)

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FUNCTIONAL ANNOTATION: PRINCIPLES AND APPLICATIONS IN OMICS STUDIES Functional annotation refers to the process of assigning biological information to genomic elementsgenes, proteins, or metabolitesbased on sequence similarity, evolutionary conservation, or curated biological knowledge