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It has a very short half-life, approximately 12 minutes, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4)
oral semaglutide) Limited long-term data and evolving patient populations for newer agents Variability in clinician-, patient-, and social mediagenerated reports The emerging role of AI-enabled pharmacovigilance systems like FDA Sentinel and SONAR As incretin-based therapies proliferate, rigorous, mechanism-aware surveillance is essential to ensure patient safety, transparency, and trust in diabetes care
Among the factors influencing its duration are injection site, treatment frequency, tissue injury severity, and individual metabolism
doi: 10.3389/fcell.2020.602574 202 TsilidisKKKasimisJCLopezDSNtzaniEEIoannidisJP
2020;67:e28138
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