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however, stratified analyses also incorporated mildly reduced ejection fractions (4549%), where clinically significant overlap with HFmrEF populations existed

Next came dualagonists such as tirzepatide (Mounjaro, Zepbound, etc), which activate both GLP1 and GIP receptors

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Reported EC values in transfected cell assays sit in the sub-nanomolar to low-nanomolar range at MC1R and MC4R, with roughly an order of magnitude lower potency at MC3R and MC5R, and it is essentially inactive at MC2R, the adrenocorticotropin receptor