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Astrocytic endfeet appear swollen under certain pathological conditions such as ischemic stroke [50], which has been associated with changes in osmotic homeostasis in response to the release of factors such as L-glutamate of K + from parenchymal brain cells

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In cognitively normal older adults, increased iron content in cortical and subcortical gray matter regions has been significantly associated with reductions in overall memory performance and immediate recall ability (Kahn-Kirby et al., 2019)

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No published, adequately controlled human trial establishing the safety, pharmacokinetics, effective exposure or clinical benefit of 5-Amino-1MQ was identified for this article