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Peptide hormones work by binding to specific receptors on the surface of target cells, initiating a cascade of intracellular events that result in the desired biological effect

Patients can reduce dosing frequency once their target level is maintained

In the STEP 1 trial, participants taking the 2.4 mg dose of semaglutide achieved an average weight loss of 14.9% of their initial body weight over 68 weeks, compared to just 2.4% in the placebo group

In a Phase 2 of Phase 1/2 trial, patients on MET-097i showed a mean placebo-adjusted body weight of 11.3% after 12 weekly doses of 1.2 mg and 7.2% after 12 weekly doses of 0.6 mg

Collectively, these studies allowed us to analyze metabolomic profiles in these cohorts