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A BMI of 27 or higher with at least one weight-related health condition, such as high blood pressure or type 2 diabetes

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Moreover, in lipopolysaccharide (LPS)-treated mice or primary microglial cultures, increasing NADH levels reversed the protective effects of glycolytic inhibition, driving NF-B-mediated proinflammatory gene expression (IL1, IL6, and iNOS) through dimerization of the NAD(H)-sensitive transcriptional corepressor CtBP [66]

Cancer cells produce more spatially concentrated ROS than normal cells, which hyperactivates the cell signaling pathways required for cellular transformation and carcinogenesis (Figure 2)