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However, in vitro potency does not predict clinical efficacy

Whether the cumulative risk of repeated switching exceeds the risk of staying on one medication long-term remains unknown

J Venom Anim Toxins Incl Trop Dis 16:402413 Singh J, Singh J, Kumar N, Jishtu V, Sharma S, Dhupper R (2017) Ethno-medicinal plants used by indigenous people of Kanda Range, Chopal forest division, Himachal Pradesh

For example, the metabolism of nitroglycerin requires interaction with thiols such as cysteine and GSH for transformation to vasoactive metabolites such as nitrosothiols or nitric oxide

Anything else means the solution is compromised