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In clinical trials of obese patients, tirzepatide showed even more impressive results in terms of weight loss from baseline, with an average reduction of 20-24%, and in some cases more than 30%, and became the first drug to outperform bariatric surgery (surgical procedures on the stomach and intestines aimed at treating obesity) in terms of effectiveness in studies

GIP receptor activation: Augments insulin secretion, promotes adipocyte lipid uptake under fed conditions, and may contribute to central appetite modulation through pathways distinct from GLP-1R

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