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Melatonin acts as an antioxidant agent that detoxifies accumulated reactive oxygen or nitrogen species or modulates the balance of pro-oxidant and anti-oxidant enzyme activities by inhibiting pro-oxidative enzymes like xanthine oxidase (XO) and activating antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD) [15, 199]
Niacinamide (20%) strong option for stubborn pigmentation but may irritate
Most participants reported no side effects at this dose
Klein & Hobai (2023) : Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report This case report detailed retained food in the stomach of a patient taking semaglutide despite following preoperative fasting guidelines, resulting in intraoperative pulmonary aspiration