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Together, these signaling systems provide a framework for investigating how angiogenic signaling, cytoskeletal organization, and fibroblast-mediated extracellular matrix processes interact in laboratory models of tendon, ligament, and musculoskeletal tissue biology

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Hesperidin suppresses the receptor for advanced glycation end products (RAGE) activity and NF-B signaling, while activating the Akt/Nrf2 pathway, thereby reducing inflammation and oxidative stress (Hong and An, 2018)