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ASCL4 plays a crucial role in synthesizing phospholipids that contain arachidonic acid, which are particularly vulnerable to oxidation during ferroptosis

doi: 10.1038/s41598-021-01663-y 60

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The choice between these mechanisms is not simply 'bigger is better.' Some patients achieve optimal results with single-receptor GLP-1 activation due to better tolerability, lower side-effect burden, or genetic predispositions favoring the GLP-1 pathway

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