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1 It is also indicated to reduce the risk of major adverse cardiovascular events (MACE) such as death, heart attack, or stroke in adults with overweight or obesity and established cardiovascular disease

Short-term effects of semaglutide among patients with obesity with and without food addiction: an observational study

Notably, weight-specific patterns emerged in serious adverse events: papillary thyroid carcinoma demonstrated significantly higher incidence in the high-weight cohort compared to other groups (p 360 days)

Fatigue typically resolves by week six to eight, replaced by improved energy as weight loss progresses and sleep quality improves

Over time, those small shortfalls add up