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The 0.01 mg/kg dose that showed consistent effects in rats translates to approximately 0.0016 to 0.004 mg/kg in humans, which works out to roughly 0.112 to 0.28 mg for a 154-pound person

To validate the clinical relevance of these findings, we examined the expression of VRK2 and SLC7A11 in PC patient-derived cancer cells (PDCs)

in bile duct ligation-induced liver cirrhosis (prevention and reversal of portal hypertension) (Sever et al., 2019)

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