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Common symptoms signaling inflammation in reproductive tissues: Pelvic or testicular pain that persists beyond acute injury Irregular menstrual bleeding or heavy menses Painful intercourse or ejaculation Unexplained low-grade fever or malaise Changes in appetite, weight loss, or altered bowel habits Reduced sexual function or libido Treating inflammation upfront minimizes scarring, maintains error-free hormone signaling, and preserves fertility potential

Our findings indicated that treatment with 5 M RSL3 reduced PB1 extrusion rate to a level comparable to that of untreated aged oocytes (Supplementary Fig