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maca root is a great alternative to caffeine because it helps boost energy and endurance while reducing anxiety and stress something that caffeine is unable to do

154 However, HIF-1 in islets is decreased in T2D, by hyperglycemia through inhibiting the HIF-1-HIF-1 dimer formation, and by NEFAs through increasing the proteolysis, leading to inability to initiate hypoxic adaptive responses

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It may also mitigate the cognitive side effects of chemotherapy, particularly in pediatric oncology ( 12, 13 )

Heres what randomized clinical trials show: Concussion recovery: A randomized placebo-controlled trial investigated the efficacy of supplemental riboflavin for concussions