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By contrast, routine initiation is generally not indicated for lean PCOS or for patients with low cardiometabolic risk, except in selected circumstances (e.g., specific metabolic indications) or within research protocols

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The Trial The ATTAIN-MAINTAIN trial enrolled patients who had achieved substantial weight loss that had plateaued while taking weekly injectable GLP-1s in the SURMOUNT-5 trial

Class-B GPCR activation: is ligand helix-capping the key