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Incretin therapy is used either with GLP-1 receptor agonists or with inhibitors of DPP-4, which is the enzyme that inactivates endogenously released GLP-1

Severe kidney disease can be problematic because kidneys must process detoxification byproducts

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Recurrent episodes in a separate pre-clinical OM model also demonstrated continuous microevolution of a haemoglobin-binding gene that resulted in a highly invasive NTHi phenotype that persisted for at least one month following clinical resolution of the infection (Harrison et al., 2020)

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