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Are oral peptides safe

The oral capsule format is designed for gastrointestinal pharmacology studies investigating local GI effects (gastric ulcer models, IBD models) and systemic bioavailability via the oral route

However, those studies were done on the elderly and not on athletes, so more research needs to be done

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In addition, since mitochondrial dysfunction leads to the activation of apoptosis, SIRT1 can directly regulate the apoptotic process by modulating acetylation of PGC-1 (Zhang et al., 2019)