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SGLT2is and NAFLD/NASH risk Although the exact mechanisms of the hepatic effect of SGLT2i therapy remain unclear, several possible hypotheses have been proposed to support the decreased risk of NAFLD following this treatment

Metabolic Health Benefits Beyond Weight Loss Weight loss represents the headline result, but both medications produce significant improvements in metabolic health markers that matter for long-term outcomes

GIP receptor activation complements the effects of GLP-1, further enhancing satiety and helping the body process and store nutrients more efficiently

Invest 116 , 32403251 (2006)

Hence, the higher vomiting and nausea rates