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Polymer-based DDSs use synthetic (e.g., PLGA) or natural polymers (e.g., chitosan) to fabricate nanocapsules, hydrogels, or microneedle arrays, enabling prolonged drug release profiles particularly advantageous for chronic hyperuricemia management (Ng et al., 2022)

Additionally, six normal mice served as controls

SCFAs have previously been implicated in processes such as gastrointestinal function, blood-pressure regulation, circadian rhythm, and immune function, and more recently explored for the effects on BBB physiology [143]

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