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Hormone Replacement Therapy Hormone Replacement Therapy (HRT) is a medical treatment designed to alleviate symptoms associated with hormonal imbalances, particularly those occurring during menopause and perimenopause

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As type 2 diabetes has a multifactorial pathogenesis, there is an urgent need for differently acting pharmacological compounds at different stages of the disease

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Bile acids, transformed from primary to secondary forms by bacteria including Clostridium bolteae and Bacteroides, activate TGR5 receptors and antagonize FXR signaling on L cells, both of which promote GLP-1 synthesis and release