Confidence in this view is moderate to high for typical outpatients, but evidence is more limited for people with complex medical conditions
Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, with no current MHRA or EMA marketing authorisation
Weeks 13-32: steady loss (1-2 pounds weekly), minimal side effects
PubMed pubmed.ncbi.nlm.nih.gov [32] Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial ScienceDirect science/article/pii/S0140673624014983 [33] Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial ScienceDirect science/article/pii/S0140673624014983 [34] Safety profile of semaglutide versus placebo in the SELECT study: a randomized controlled trial PubMed pubmed.ncbi.nlm.nih.gov [35] Safety profile of semaglutide versus placebo in the SELECT study: a randomized controlled trial PubMed pubmed.ncbi.nlm.nih.gov [36] Safety and efficacy of glucagon-like peptide-1 receptor agonists on cardiovascular events in overweight or obese non-diabetic patients ScienceDirect science/article/abs/pii/S0146280624000422 [37] Safety and efficacy of glucagon-like peptide-1 receptor agonists on cardiovascular events in overweight or obese non-diabetic patients PubMed pubmed.ncbi.nlm.nih.gov [38] Safety and efficacy of glucagon-like peptide-1 receptor agonists on cardiovascular events in overweight or obese non-diabetic patients PubMed pubmed.ncbi.nlm.nih.gov [39] Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics PubMed pubmed.ncbi.nlm.nih.gov [40] Safety profile of semaglutide versus placebo in the SELECT study: a randomized controlled trial PubMed pubmed.ncbi.nlm.nih.gov [41] Safety profile of semaglutide versus placebo in the SELECT study: a randomized controlled trial PubMed pubmed.ncbi.nlm.nih.gov [45] Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes PubMed pubmed.ncbi.nlm.nih.gov [46] Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial PubMed pubmed.ncbi.nlm.nih.gov [47] Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis PubMed pubmed.ncbi.nlm.nih.gov [48] Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis PubMed pubmed.ncbi.nlm.nih.gov [49] Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial PubMed pubmed.ncbi.nlm.nih.gov [50] Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes PubMed pubmed.ncbi.nlm.nih.gov [51] Efficacy and safety of GLP-1RAs for people with obesity: A systematic review based on RCT and Bayesian network meta-analysis ScienceDirect science/article/pii/S0753332224000313 [52] GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review ScienceDirect science/article/pii/S2589537024003614 [53] Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes PubMed pubmed.ncbi.nlm.nih.gov [54] Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial PubMed pubmed.ncbi.nlm.nih.gov [55] Efficacy and safety of GLP-1RAs for people with obesity: A systematic review based on RCT and Bayesian network meta-analysis ScienceDirect science/article/pii/S0753332224000313 [56] GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review ScienceDirect science/article/pii/S2589537024003614 [57] GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)
But that doesnt mean that Part D plans never cover weight-loss drugs
