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5 This depletion is linked to major risk factors such as obesity and hypertension, which contribute to the development of conditions like atherosclerosis and cardiomyopathies

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Epigenetic modifications, such as DNA methylation of pro-inflammatory cytokine genes (TNF-, IL-6, and IL-1), further influence RA progression, suggesting targets for nanotechnology-based gene regulation and therapeutic intervention (11)

Protocol timing is highly variable and depends on the research goals