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10.1038/nrdp.2015.56 149 MelliosN.SugiharaH.CastroJ.BanerjeeA.LeC.KumarA.et al

Additionally, the gut microbiome influences the immune system, including intestinal and extra-intestinal organs (22, 23)

Berkman AM, Andersen CR, Puthenpura V, Short NJ, Merriman K, Swaminathan M, Cuglievan B, McCall D, DiNardo C, Nunez C, Jain N, Kadia T, Issa G, Gibson A, Garcia MB, Livingston JA, Parsons S, Hildebrandt MAT , Roth ME

Supplemental NMN is shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders

We agree with commenters that standardization facilitates more actionable comparisons of the MRF data, and that over time standardization will reduce burden to hospitals and payers