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A study published in a quality-of-life journal found that patients who switched from oral semaglutide to tirzepatide due to insufficient weight reduction experienced significant improvements in quality of life as early as 3 months after the switch

Some patients taper off successfully

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In addition, new compounds known to stimulate the release of GH, known as GH secretagogues or ghrelin mimetics, are also in clinical development (NCT02558829)