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Plaintiffs point to pre-approval clinical trials and post-marketing adverse event reports that accumulated evidence of severe gastrointestinal complications years before manufacturers updated warning labels to reflect these serious risks
Lactate is one of the oldest and best-established biomarkers in psychiatry, first documented as early as 1934, and major psychiatric disorders have been known to be associated with acidosis since 1932 [198, 199]
Besides, it has high linkage disequilibrium (LD r = 0.95, D = 0.98) with rs10088218, a SNP reported to be associated with ovarian cancer in GWAS
The cGAS-STING pathway was initially defined as a cytoplasmic dsDNA sensorproinflammatory response axis that triggers the production of type I interferons and a broad range of other cytokines [20]
Spermatozoa are particularly vulnerable to oxidative injury because their membranes are rich in polyunsaturated fatty acids and they possess limited cytoplasmic antioxidant reserves 54,55
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