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Guerra V, Ologun GO, Haydu LE, Keung E, Burton EM, Tawbi H, Wierda WG, Davies MA , Wargo JA, Ferrajoli A

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Because unbound drug concentration is determined by dosing rate and clearancewhich is not altered, in the case of these low-extraction-ratio drugs, by protein bindingincreases in dosing rate will cause corresponding changes in the pharmacodynamically important unbound concentration

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In this method, a volume of product is passed through a small membrane filter paper