However, which signaling pathway produces the unwanted side effects (such as respiratory suppression and constipation) is currently controversial: one view is that it is caused by -arrestin signal transduction, and the other view suggests that the respiratory depression by opioids is caused due to G protein-gated inwardly rectifying potassium (GIRK) channel signaling
Qureshi-Baig, K., Ullmann, P., Haan, S
The fundamental distinction lies in their mechanism: sulfonylureas provide continuous insulin stimulation (carrying intrinsic hypoglycaemia risk), whilst incretin mimetics offer glucose-responsive action with additional metabolic benefits beyond glycaemic control
Evaluation of the effects of topical tripeptidecopper complex and zinc oxide on openwound healing in rabbits
Many women with pcos pmos: Have clear ultrasounds But still experience symptoms And still meet diagnostic criteria But always know diagnosis can still come from factors like irregular or absent cycles, elevated androgens (testosterone, DHEA-S), along with signs of insulin resistance So if your scan was normal but your symptoms weren't, trust me when I say your experience is still valid and in fact worth investigating
