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reported one patient with 3-methylglutaric aciduria displayed thinning of the corpus callosum, enlarged lateral and third ventricles, and basal ganglia atrophy in cranial MRI

It is longer, more gradual, and more immersive

This apoptotic effect can be rescued by cholesterol supplementation but not by lanosterol, highlighting the functional importance of downstream cholesterol synthesis in cell survival [7]

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Collectively, while ferroptosis plays a significant role in the pathogenesis of both TMJ OA and KOA, the specific effects may differ due to the distinct tissue characteristics, mechanical stress, and inflammatory environments of TMJ and knee