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Safety Considerations: Tirzepatide is not recommended for those with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, a history of pancreatitis, or severe gastrointestinal disease

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(2) Patients with major heart, liver, kidney, and other organ disorders, including co-infection with hepatitis C virus (HCV), hepatitis D virus (HDV), or other chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), and autoimmune hepatitis

64 These agents inhibit the production of TNF-alfa, a proinflammatory cytokine implicated in the pathogenesis of UC

In one trial, liraglutide slowed brain volume loss by 50% and reduced memory loss over a 12-month period