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The PVN modulates appetite and energy expenditure via hormones like CRH and TRH, while the ARC, with its appetite-stimulating (NPY, AgRP) and satiety-promoting (POMC) neurons, regulates feeding behaviors 44,45

This was achieved by demethylating the promoters of 14-3-3, CHK2 and DAPK-1 genes, promoting the expression of these genes, and then activating the G2/M checkpoint response in osteosarcoma cells, to improve the radiotherapy effect of osteosarcoma 10 (Figure 1 and Table 1)