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In contrast, sustained or excessive ROS accumulation suppresses AMPK activity by destabilizing the AMPK-LKB1 complex, inducing inhibitory Ser485/491 phosphorylation via Akt/PKA signaling, and causing irreversible oxidative modifications of key cysteine residues (Yan et al., 2022)

It has been reported that animals receiving chronic successive administration of D-gal (50500 mg/kg) for 48 weeks experienced cognitive and memory dysfunction 24,25,30

Bottom line: Standard glutathione is easily destroyed by digestion