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while multiple metabolites trended in the same direction between CR and DL-fed mice, the only significantly altered metabolite that was shared in both CR and DL-fed mice was glucose-6-phosphate, which was decreased in the plasma of both groups (Figs

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This allows for a period of signal resolution, preventing the chronic suppression of inhibitory proteins like SOCS-3 (Suppressor of Cytokine Signaling) that often occurs with tonic stimulation

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