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MACE, major adverse cardiovascular event, MA meta-analysis

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Among the four, three new interfacial salt bridges (Figures 3, 4 and 5) were found to be formed due to the missense mutations introduced into semaglutides backbone, especially the missense mutation L23B R, whereas only one salt bridge (Table 4) was found to be formed and the same as the salt bridge (Table 1) identified in PDB entry 4ZGM [29, 52]

[PubMed: 4431434] 30