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Funding None Ethics declarations Competing interests The authors declare no competing interests
Usually, the issues are pretty minor and don't stick around for long
HD: tip of the iceberg After years or decades of impaired mitochondrial biology, the tip emerges as HD, which is typically diagnosed in the setting of involuntary hyperkinetic movements (chorea) supported by confirmatory genetic testing [153]
Their fine needles also minimize disruption to the lyophilized powder
The genetic basis of MMA is primarily associated with deficiencies in the enzyme methylmalonyl-CoA mutase (MCM) or impairments in the metabolism of its cofactor, adenosyl-cobalamin (a bioactive form of vitamin B12)
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