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The most commonly reported side effects are typically mild and transient, occasionally including minor gastrointestinal upset, nausea, or heartburn, particularly if the supplements are taken on an empty stomach or in excessively high doses all at once
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38 Collectively, all these discoveries have contributed not only to our understanding of the biological aging process, but also allowed to develop rationale intervention strategies to target molecular hallmarks of this process and biomarkers to quantify biological aging status, aiming to achieved healthy lifespan extension with precise and multitargeted approaches
PMID 24886657
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