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3 Extracellular matrix stiffness The extracellular matrix (ECM) is a key component of the tumor microenvironment, providing structural support and acting as a reservoir of cues, including biophysical signals such as matrix stiffness and viscoelasticity

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It works as an immune booster and anti-tumor agent by binding to opioid receptors (130)

Most of the pathways in this part involve cytokines, starting from MAPK, TCR, or cAMP-PKA signaling, which results in an increase in anti-inflammatory cytokines and a decrease in pro-inflammatory cytokines