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Immunosuppression, immunosenescence, and insulin resistance associated with inflammaging Immunosuppression increases with aging and age-related diseases Currently, it is known that a low-grade inflammatory process is associated with a compensatory anti-inflammatory state which involves the activation of the immunosuppressive network

Recent studies have shown that GDF-15 secreted by M2-polarized tumor-associated macrophages promotes ferroptosis resistance in AML cells by modulating the SLC7A11/GPX4 axis (Lu and Liao, 2025)

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Sleep and stress regulation Inadequate rest and chronic stress elevate cortisol, which can counteract fat loss and trigger cravings

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