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In the Surmonut-1 trial, overweight or obese patients without diabetes taking tirzepatide 15 mg averaged 20.1% placebo-subtracted weight loss, with 96.3% achieving 5% weight loss compared to 27.9% on placebo

van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML, et al

Weight also does not tell us what is actually changing

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